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NDT Advance Access originally published online on April 9, 2008
Nephrology Dialysis Transplantation 2008 23(6):1786-1789; doi:10.1093/ndt/gfn142
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Use (or misuse) of vitamin D treatment in CKD and dialysis patients

A recent meta-analysis on vitamin D compounds in chronic kidney disease [1] and an editorial comment [2] accompanying this meta-analysis have already been published. We believe that these papers deserve some comments in the interest of the NDT readership

Klaus Olgaard1 and Ewa Lewin2

1 Nephrological Department P, Rigshospitalet 2 Nephrological Department B, Herlev Hospital, University of Copenhagen, Denmark

Correspondence and offprint requests to: Klaus Olgaard, Department of Nephrology P2132, University of Copenhagen, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. Tel: +45-3545-2130; Fax: +45-3545-2672; E-mail: olgaard@rh.dk

The first 150 words of the full text of this article appear below.

1,25-Dihydroxy vitamin D (vitamin D) is a hormone with a number of pharmacological and physiological effects, first demonstrated as the effect to cure osteomalacia and later as a hormone with effects related to mineral homeostasis, cell differentiation, immunology, vascular calcification and ageing [3–5]. The hormone, 1,25-dihydroxy vitamin D, is formed from cholecalciferol, that is 25-hydroxylated in the liver and 1-{alpha}-hydroxylated in the kidney. In addition 1-{alpha}-hydroxylase activity has been demonstrated in a number of cells outside the kidney. The activity of the extrarenal 1-{alpha}-hydroxylase is, however, not enough to keep physiological plasma levels of 1,25-dihydroxy vitamin D, and the renal 1-{alpha}-hydroxylase activity is therefore of utmost importance for maintaining a normal physiological homeostasis.

In patients with chronic uraemia, reduced kidney mass and low kidney function, the renal 1-{alpha}-hydroxylase activity is clearly reduced, as demonstrated by the very low levels of plasma 1,25-dihydroxy vitamin . . . [Full Text of this Article]



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